Papers

Published & accepted

Accepted2026Conference paper

Optimizing Portfolios of Multiple Treatments for One Indication

Zaile Li, Stephen E. Chick, Shane G. Henderson

2026 Winter Simulation Conference

  • Health Innovation Pipeline

Accepted2026Conference paper

Beyond Fixed-Precision and Fixed-Budget Ranking and Selection: Economics of Selection Procedures, New and Old

Stephen E. Chick, Zaile Li, L. Jeff Hong

2026 Winter Simulation Conference

  • Simulation Optimization & Ranking and Selection

Published2025Conference paper

Explore Then Confirm: Investment Portfolios for New Drug Therapies

Zaile Li, Stephen E. Chick, Sam Daems, Shane G. Henderson

2025 Winter Simulation Conference, 3214–3225

  • Health Innovation Pipeline

Published2025Journal paper

The (Surprising) Sample Optimality of Greedy Procedures for Large-Scale Ranking and Selection

Zaile Li, Weiwei Fan, L. Jeff Hong

Management Science 71(2):1238–1259

  • Selection Among Many Alternatives

Published2025Journal paper

New Additive OCBA Procedures for Robust Ranking and Selection

Yuchen Wan, Zaile Li, L. Jeff Hong

Asia-Pacific Journal of Operational Research 42(6):2540003

  • Simulation Under Input Uncertainty

Working papers

Under revision2026Working paper

Response Adaptivity Across Clinical Trials in Portfolios of Biomedical Innovations

Zaile Li, Stephen E. Chick, Shane G. Henderson

Management Science

  • Health Innovation Pipeline

In progress2026Working paper

Can Bayesian Decision-Theoretic Clinical Trial Designs, from DeGroot to Chernoff to Today, Have Frequentist Error Control?

Stephen E. Chick, Zaile Li, David Roberson, Sofía Villar

Manuscript

  • Health Innovation Pipeline

Under review2026Working paper

Screening Virtually: Learning to Select Top Alternatives with (Almost) Free Ranking

Zaile Li, Weiwei Fan, L. Jeff Hong

Manuscript

  • Selection Among Many Alternatives

Under review2026Working paper

Sequential Additivity in Distributionally Robust Ranking and Selection

Zaile Li, Yuchen Wan, L. Jeff Hong

Manuscript

  • Simulation Under Input Uncertainty

To be submitted2026Working paper

Seeking the Best Extreme: An Old-School Perspective and the Self-Comparison Principle

Zaile Li, Yuchen Wan, L. Jeff Hong

Manuscript

  • Diverse Learning Objectives

In progress2026Working paper

Seeking the Best Extreme under a Fixed Budget

Yuchen Wan, Zaile Li, L. Jeff Hong

Manuscript

  • Diverse Learning Objectives

To be submitted2026Working paper

Economics of Selection in Ranking & Selection: Neither Fixed-Precision nor Fixed-Budget

Stephen E. Chick, Zaile Li, L. Jeff Hong

Manuscript

  • Simulation Optimization & Ranking and Selection

Under revision2025Working paper

UCB for Large-Scale Pure Exploration: Beyond Sub-Gaussianity

Zaile Li, Weiwei Fan, L. Jeff Hong

Operations Research

  • Selection Among Many Alternatives